The Ducati rider's eighth victory of the season, his third consecutive win, gave him an 85-point lead over Italy's Valentino Rossi.
Images from the 2020 Euro Championships qualifiers played on Saturday
Higuain had a disappointing Copa America tournament in July, scoring two goals during the competition and missing his spot kick as Argentina lost on penalties to Chile in the final.
Carlos Tevez scored twice for Boca Juniors on Saturday but the main talking point from their 3-1 win over Argentinos Juniors in a stormy Argentine league game was his studs-up challenge that left defender Ezequiel Ham with a broken ankle.
News of all that's transpired on and off the football field
New strikers Carlos Bacca and Luiz Adriano bagged their maiden Serie A goals to give AC Milan their first points of the season with a 2-1 home win over Empoli on Saturday.
Carlos Tevez scored his first goal for Boca Juniors at La Bombonera in more than a decade but it was not enough to prevent his side from crashing to a shock 4-3 defeat to Union in the Argentine championship on Sunday.
Juventus refused to let up despite having already won Serie A and notched their 25th win in their last 26 league games by beating Carpi 2-0 on Sunday.
Striker Jonathan Calleri chipped a brilliant 'rabona' as Boca Juniors marked Carlos Tevez's homecoming with a 2-1 victory over Quilmes at La Bombonera to stay top of the Argentine championship.
Carlos Tevez was officially unveiled as a Boca Juniors player in a 6.5 million euros ($7.15 million) transfer from Juventus.
IMAGES from La Liga matches played on Sunday
News of all that's transpired on and off the football field.
An Aaron Ramsey strike and a Kalidou Koulibaly own goal gave Arsenal a 2-0 victory over Napoli in the first leg of their Europa League quarter-final, while Chelsea beat a stubborn Slavia Prague 1-0.
Most of the deaths are related to fights between the barras bravas, Argentina's hooligan firms.
News of all that's transpired on and off the football field
IMAGES from the Euro 2020 qualifiers played on Thursday
Three time European champions Inter Milan were stunned 2-0 at home by Israeli side Hapoel Beer-Sheva and Manchester United were floored by a late goal from Feyenoord as the Europa League group stage got underway on Thursday.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
A round-up of results from the Nations League matches played on Sunday
Genoa handed Serie A leaders and titleholders Juventus a dramatic first league defeat of the season when Luca Antonini scored in the fourth minute of stoppage time to give them a 1-0 win on Wednesday.
News of all that's transpired on and off the football field
Lazio survived a storming Napoli fight back, including a missed penalty, as they won 4-2 on Sunday to finish third in Serie A and qualify for the Champions League playoff round after both teams finished with 10 men.
The Libertadores Cup derby between Boca Juniors and River Plate was called off at halftime on Thursday after River players were sprayed with an irritant by a fan of their bitter rivals.
Real Madrid playmaker Kaka expects a friendly reception when he returns to AC Milan for their Champions League encounter on Wednesday but the Brazilian is not making any predictions about the score.
Alessandro Florenzi ran more than half the length of the field to score and cap a 2-0 win for AS Roma over Genoa which took them back into second place in Serie A on Sunday.
Lazio squandered a two-goal lead against Inter Milan as they drew 2-2 at the San Siro on Sunday and wasted a golden chance to take sole possession of third spot in Serie A.
United States President Barack Obama has warned that horrific mass shooting incidents like the recent one in Orlando will continue to occur unless tougher gun control laws are adopted.
Villarreal continued their impressive revival after a season in the second division when Jeremy Perbet and Jonathan Pereira struck in a 2-1 win at home to Espanyol in La Liga on Thursday.
Juventus striker Carlos Tevez struck to give the Serie A champions a 1-0 win over AC Milan on Saturday, handing coach Massimiliano Allegri a winning return to San Siro where he was shown the door eight months ago.
Amid growing anti-Muslim rhetoric in the US poll campaign, President Barack Obama today made his first visit to a mosque as part of his effort to assure the religious minority of their safety and security and celebrate religious diversity of the country.
The Fernando Llorente and Carlos Tevez double act struck again on Sunday with both players scoring to give Juventus a 2-0 win at AC Milan which strengthened their grip on Serie A.
AC Milan's season slumped to a new low on Sunday as they had two players sent off and lost 2-1 at Udinese while the bizarre postponement of the Cagliari-AS Roma match further damaged Serie A's fading credibility.
New Liverpool boss Juergen Klopp made it three wins from his last three matches with a 1-0 success at Rubin Kazan in Russia that left them second in Group B, two points behind Swiss club Sion on Thursday.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
AC Milan were booed off the pitch after suffering a shock 1-0 home defeat by Atalanta in Serie A on Saturday following a second-half Luca Cigarini strike that stunned the San Siro.
Samuel Eto'o scored twice as Inter Milan swatted aside Bologna 4-1 on Saturday to record their fourth successive win under new coach Leonardo and continue their ominous climb up the Serie A table.
Tiny Cape Verde Islands catapulted themselves into surprise World Cup contention with a 2-1 victory away to South Africa.